Effect of estradiol -17 β on arachidonic acid metabolism in sheep uterus: in vitro studies
نویسندگان
چکیده
The effect of estradiol-17 β on Arachidonic acid (AA) metabolism in non-pregnant sheep uterus was studied under in vitro conditions. On incubation of uterine slices with estradiol-17β, the levels of prostaglandins were altered but not Lipoxygenase (LOX) products. Based on their analysis on conventional TLC technique, the Cyclooxygenase (COX) products PGF2α, 6-keto PGF1α and PGE2 were shown to be altered over an incubation period of 0 to 120 minutes. The LOX products, HPETEs and HETEs did not show any change upon incubation with estradiol-17β. This study gives a preliminary understanding of role of estradiol on AA metabolism.
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